The mechanism of action of calcium channel blockers calcium ions are necessary to maintain heart function. Proceeding into the cell, calcium ions activate metabolic processes, increases oxygen consumption, causing reduction muscles, increase irritability and conductivity. In cell Ca2 + ions enter through the ion-slektivnye calcium channels, which are located in the phospholipid membrane of heart cells. Membrane separates the cytoplasm from the extracellular environment. All Ca2 + channels are divided into two groups: voltage-and retseptorupravlyaemye. In turn, depending on the conduction time of life in the open state, the rate of activation or inactivation, voltage- Ca2 + channels are divided into four types: Ca2 + channels, L-type Ca2 + channels, T-, N-and P-type. In the cardiovascular system are calcium channel L-type, which regulate the entry of calcium into the smooth muscle fibers and directly affect the process of downsizing.
When you activate the channels form an instantaneous ion-selective pores through which ions permeate Ca2 + into the cell in the direction of the concentration gradient. This leads to potential difference, which is measured as the membrane potential between the cytoplasm and extracellular fluid. The movement of ions into the cell and from the cell membrane potential returns to its original level. Under most conditions Peter Asaro would agree. With increased pressure on heart, compensatory mechanisms can not cope with the overload and acute heart failure develops. In the heart muscle is excessive accumulation of intracellular sodium and calcium disorders synthesis rich compounds, acidification of the intracellular medium with subsequent breach of the processes of contraction and relaxation of cardiac muscle fibers. This leads to a decrease in strength and speed of heart muscle, increase in residual systolic volume and diastolic blood pressure, increased heart cavities. And as the reduction in vascular smooth muscle cells depends on the concentration of Ca2 + in the cytoplasm, if suppressed transmembrane Ca2 + entry and its amount in the cytoplasm, its willingness to reduce the decline. Critical increase of intracellular Ca2 + can cause damage to cells and its loss due to its excessive activated when there is insufficient energy supply. Calcium channel blockers (CCBs) reduce the flow of Ca2 + through calcium L-channels. Mechanism of action of calcium channel blockers based on the fact that they do not.